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Add protein-translation exercise #122

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8 changes: 8 additions & 0 deletions config.json
Original file line number Diff line number Diff line change
Expand Up @@ -343,6 +343,14 @@
"prerequisites": [],
"difficulty": 3
},
{
"slug": "protein-translation",
"name": "Protein Translation",
"uuid": "94130e39-1026-4d8e-9715-9c926215c470",
"practices": [],
"prerequisites": [],
"difficulty": 3
},
{
"slug": "queen-attack",
"name": "Queen Attack",
Expand Down
45 changes: 45 additions & 0 deletions exercises/practice/protein-translation/.docs/instructions.md
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# Instructions

Translate RNA sequences into proteins.

RNA can be broken into three nucleotide sequences called codons, and then translated to a polypeptide like so:

RNA: `"AUGUUUUCU"` => translates to

Codons: `"AUG", "UUU", "UCU"`
=> which become a polypeptide with the following sequence =>

Protein: `"Methionine", "Phenylalanine", "Serine"`

There are 64 codons which in turn correspond to 20 amino acids; however, all of the codon sequences and resulting amino acids are not important in this exercise.
If it works for one codon, the program should work for all of them.
However, feel free to expand the list in the test suite to include them all.

There are also three terminating codons (also known as 'STOP' codons); if any of these codons are encountered (by the ribosome), all translation ends and the protein is terminated.

All subsequent codons after are ignored, like this:

RNA: `"AUGUUUUCUUAAAUG"` =>

Codons: `"AUG", "UUU", "UCU", "UAA", "AUG"` =>

Protein: `"Methionine", "Phenylalanine", "Serine"`

Note the stop codon `"UAA"` terminates the translation and the final methionine is not translated into the protein sequence.

Below are the codons and resulting Amino Acids needed for the exercise.

| Codon | Protein |
| :----------------- | :------------ |
| AUG | Methionine |
| UUU, UUC | Phenylalanine |
| UUA, UUG | Leucine |
| UCU, UCC, UCA, UCG | Serine |
| UAU, UAC | Tyrosine |
| UGU, UGC | Cysteine |
| UGG | Tryptophan |
| UAA, UAG, UGA | STOP |

Learn more about [protein translation on Wikipedia][protein-translation].

[protein-translation]: https://en.wikipedia.org/wiki/Translation_(biology)
40 changes: 40 additions & 0 deletions exercises/practice/protein-translation/.meta/Example.roc
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module [toProtein]

Codon : List U8
AminoAcid : [Cysteine, Leucine, Methionine, Phenylalanine, Serine, Tryptophan, Tyrosine]
Protein : List AminoAcid

toInstruction : Codon -> Result [Append AminoAcid, Stop] [KeyNotFound]
toInstruction = \codon ->
Dict.fromList [
(['A', 'U', 'G'], Append Methionine),
(['U', 'U', 'U'], Append Phenylalanine),
(['U', 'U', 'C'], Append Phenylalanine),
(['U', 'U', 'A'], Append Leucine),
(['U', 'U', 'G'], Append Leucine),
(['U', 'C', 'U'], Append Serine),
(['U', 'C', 'C'], Append Serine),
(['U', 'C', 'A'], Append Serine),
(['U', 'C', 'G'], Append Serine),
(['U', 'A', 'U'], Append Tyrosine),
(['U', 'A', 'C'], Append Tyrosine),
(['U', 'G', 'U'], Append Cysteine),
(['U', 'G', 'C'], Append Cysteine),
(['U', 'G', 'G'], Append Tryptophan),
(['U', 'A', 'A'], Stop),
(['U', 'A', 'G'], Stop),
(['U', 'G', 'A'], Stop),
]
|> Dict.get codon
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toProtein : Str -> Result Protein [InvalidCodon Codon]
toProtein = \rna ->
rna
|> Str.toUtf8
|> List.chunksOf 3
|> List.walkUntil [] \protein, codon ->
when codon |> toInstruction is
Ok (Append aminoAcid) -> protein |> List.append (Ok aminoAcid) |> Continue
Ok Stop -> Break protein
Err KeyNotFound -> protein |> List.append (Err (InvalidCodon codon)) |> Break
|> List.mapTry \id -> id
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18 changes: 18 additions & 0 deletions exercises/practice/protein-translation/.meta/config.json
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{
"authors": [
"ageron"
],
"files": {
"solution": [
"ProteinTranslation.roc"
],
"test": [
"protein-translation-test.roc"
],
"example": [
".meta/Example.roc"
]
},
"blurb": "Translate RNA sequences into proteins.",
"source": "Tyler Long"
}
19 changes: 19 additions & 0 deletions exercises/practice/protein-translation/.meta/template.j2
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{%- import "generator_macros.j2" as macros with context -%}
{{ macros.canonical_ref() }}
{{ macros.header() }}

import {{ exercise | to_pascal }} exposing [toProtein]

{% for case in cases -%}
# {{ case["description"] }}
expect
rna = {{ case["input"]["strand"] | to_roc }}
result = rna |> toProtein
{%- if case["expected"]["error"] %}
result |> Result.isErr
{%- else %}
result == Ok [{%- for aminoAcid in case["expected"] -%}{{ aminoAcid | to_pascal }}, {%- endfor %}]
{%- endif %}

{% endfor %}

105 changes: 105 additions & 0 deletions exercises/practice/protein-translation/.meta/tests.toml
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# This is an auto-generated file.
#
# Regenerating this file via `configlet sync` will:
# - Recreate every `description` key/value pair
# - Recreate every `reimplements` key/value pair, where they exist in problem-specifications
# - Remove any `include = true` key/value pair (an omitted `include` key implies inclusion)
# - Preserve any other key/value pair
#
# As user-added comments (using the # character) will be removed when this file
# is regenerated, comments can be added via a `comment` key.

[2c44f7bf-ba20-43f7-a3bf-f2219c0c3f98]
description = "Empty RNA sequence results in no proteins"

[96d3d44f-34a2-4db4-84cd-fff523e069be]
description = "Methionine RNA sequence"

[1b4c56d8-d69f-44eb-be0e-7b17546143d9]
description = "Phenylalanine RNA sequence 1"

[81b53646-bd57-4732-b2cb-6b1880e36d11]
description = "Phenylalanine RNA sequence 2"

[42f69d4f-19d2-4d2c-a8b0-f0ae9ee1b6b4]
description = "Leucine RNA sequence 1"

[ac5edadd-08ed-40a3-b2b9-d82bb50424c4]
description = "Leucine RNA sequence 2"

[8bc36e22-f984-44c3-9f6b-ee5d4e73f120]
description = "Serine RNA sequence 1"

[5c3fa5da-4268-44e5-9f4b-f016ccf90131]
description = "Serine RNA sequence 2"

[00579891-b594-42b4-96dc-7ff8bf519606]
description = "Serine RNA sequence 3"

[08c61c3b-fa34-4950-8c4a-133945570ef6]
description = "Serine RNA sequence 4"

[54e1e7d8-63c0-456d-91d2-062c72f8eef5]
description = "Tyrosine RNA sequence 1"

[47bcfba2-9d72-46ad-bbce-22f7666b7eb1]
description = "Tyrosine RNA sequence 2"

[3a691829-fe72-43a7-8c8e-1bd083163f72]
description = "Cysteine RNA sequence 1"

[1b6f8a26-ca2f-43b8-8262-3ee446021767]
description = "Cysteine RNA sequence 2"

[1e91c1eb-02c0-48a0-9e35-168ad0cb5f39]
description = "Tryptophan RNA sequence"

[e547af0b-aeab-49c7-9f13-801773a73557]
description = "STOP codon RNA sequence 1"

[67640947-ff02-4f23-a2ef-816f8a2ba72e]
description = "STOP codon RNA sequence 2"

[9c2ad527-ebc9-4ace-808b-2b6447cb54cb]
description = "STOP codon RNA sequence 3"

[f4d9d8ee-00a8-47bf-a1e3-1641d4428e54]
description = "Sequence of two protein codons translates into proteins"

[dd22eef3-b4f1-4ad6-bb0b-27093c090a9d]
description = "Sequence of two different protein codons translates into proteins"

[d0f295df-fb70-425c-946c-ec2ec185388e]
description = "Translate RNA strand into correct protein list"

[e30e8505-97ec-4e5f-a73e-5726a1faa1f4]
description = "Translation stops if STOP codon at beginning of sequence"

[5358a20b-6f4c-4893-bce4-f929001710f3]
description = "Translation stops if STOP codon at end of two-codon sequence"

[ba16703a-1a55-482f-bb07-b21eef5093a3]
description = "Translation stops if STOP codon at end of three-codon sequence"

[4089bb5a-d5b4-4e71-b79e-b8d1f14a2911]
description = "Translation stops if STOP codon in middle of three-codon sequence"

[2c2a2a60-401f-4a80-b977-e0715b23b93d]
description = "Translation stops if STOP codon in middle of six-codon sequence"

[f6f92714-769f-4187-9524-e353e8a41a80]
description = "Sequence of two non-STOP codons does not translate to a STOP codon"

[1e75ea2a-f907-4994-ae5c-118632a1cb0f]
description = "Non-existing codon can't translate"
include = false

[9eac93f3-627a-4c90-8653-6d0a0595bc6f]
description = "Unknown amino acids, not part of a codon, can't translate"
reimplements = "1e75ea2a-f907-4994-ae5c-118632a1cb0f"

[9d73899f-e68e-4291-b1e2-7bf87c00f024]
description = "Incomplete RNA sequence can't translate"

[43945cf7-9968-402d-ab9f-b8a28750b050]
description = "Incomplete RNA sequence can translate if valid until a STOP codon"
8 changes: 8 additions & 0 deletions exercises/practice/protein-translation/ProteinTranslation.roc
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@@ -0,0 +1,8 @@
module [toProtein]

AminoAcid : [Cysteine, Leucine, Methionine, Phenylalanine, Serine, Tryptophan, Tyrosine]
Protein : List AminoAcid

toProtein : Str -> Result Protein _
toProtein = \rna ->
crash "Please implement the 'toProtein' function"
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