readme.md

Thesis Outline

The Genetics of Aggressive Behavior

(( Literature Review ))

1. Intro
   • Introduction to the topic
   • Summary of the literature review
2. Definition of Aggressive behavior
   • general definition
   • Types of aggressive behavior
     • Hostile and Instrumental aggression
     • direct and indirect aggression
3. Evolutionary Theories about aggressive behavior
   • sexual selection theory
     • definition
     • application to aggression
   • evolutionary advantages
   • evolutionary disadvantages
   • stabilizing selection
   • predictions
4. Methods used to investigate the genetics of aggression in humans

• Twin and adoption studies
  • General Method of SEM
  • heritability estimations
• GWAS and other molecular genetic studies on humans
  • general method of GWAS
  • methods of rare variants
  • Heritability estimations
• Missing heritability
• Genetic Correlation and cross-phenotype overlap

6. Gap in the literature
   • Conclusion
   • paragraph introducing studies

The Longitudinal Heritability of childhood aggression

(( Content of the paper ))

1. Introduction
2. Material and Methods
   • Data
   • Method
3. Results
   • Descriptives
   • Longitudinal Genetic Modeling
4. Discussion

The heritability of childhood aggression - A Mega Analysis

requires permission from Meike and Dorret

1. Introduction
2. Material and Methods
   • Data
   • Method
3. Results
   • Descriptives
   • Results
4. Discussion

Genome Wide Association Study on impulsive aggressive behavior

(( UK Biobank ))

1. Introduction
   • past GWAS
   • past molecular studies and genes of interest
2. Material and Methods
   • Data
   • Method
3. Results
   • Descriptives
   • Results
4. Discussion

Genetic and Phenotypic Correlation of Aggressive behavior and other impulsive inhibitions

(( UK Biobank ))

1. Introduction
   • impulse control
     • addiction
     • aggression as an impulse control disorder
   • methods on genetic correlations
2. Material and Methods
   • Data
     • selected phenotypes
   • Method
     • GCTA
     • LD-Regresssion
3. Results
   • Descriptives
   • Results
4. Discussion

The KSburden Test - A simple gene based test for distributional differences

(( KS test ))

1. Introduction
2. Material and Methods
   • Simulations
   • Real Data
     • UKB
     • DDD data
3. Results
   • Simulation results
   • Real data results
4. Discussion

Estimation of Cultural Transmission via polygenic risk scores

(( ALSPAC data ))

1. Introduction
2. Material and Methods
   • Simulations
   • Real Data
3. Results
   • Simulation results
   • Real data results 4� Discussion