ACMG variant grading

[boschann]

Based on the Clingen recommended ACMG criteria grading, i would suggest to update the VarFish ACMG lis:
"For strength-modified evidence, SVI recommends using the original criteria code followed by an underscore and new level of
strength. This shifting of criteria weight is especially important for quantitative evidence types."
Thus their should be the possibility to modify the strength evidence in the displayed "ACMG"-Box: strong, medium, supporting
https://clinicalgenome.org/site/assets/files/3459/svi_criteria_nomenclature_recommendation_v1.pdf

[boschann]

Furthermore, absence or low frequency in gnomAD should be classified as a supporting criteria: PM2_sup https://clinicalgenome.org/site/assets/files/5182/pm2_-_svi_recommendation_-_approved_sept2020.pdf

[holtgrewe]

This is easy to do in principle but we need to start recording the version of the ACMG rating used.

[holtgrewe]

I wonder how the additional grading would work UI wise. It looks to me that things would be complicated by this.

We would have to add another three check boxes for each criterion. Doable but needs some mediation.

[holtgrewe]

#476 #477