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Implement some heuristics to sanity check the tumor and normal matching #143

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armish opened this issue Jan 30, 2017 · 0 comments
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@armish
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armish commented Jan 30, 2017

Things that can go wrong here include:

  • Mismatched sequencing platform
  • Sample mismatch/mix-up
  • ...

And these can easily lead to some unexpected variant calling behavior (e.g. having tens of thousands of filter-passing somatic variants). Potentially, metrics extracted from the BAM file (and during the QC process) might help with implementing such heuristics — e.g. read length, # of reads, information content...

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