diff --git a/mu-plugins/blocks/notice/index.php b/mu-plugins/blocks/notice/index.php
index 87fc2d48..d6cedc48 100644
--- a/mu-plugins/blocks/notice/index.php
+++ b/mu-plugins/blocks/notice/index.php
@@ -49,12 +49,19 @@ function render_callout_as_notice( $attr, $content, $tag ) {
 
 	// Sanitize message content.
 	$content = wp_kses_post( $content );
-	// Temporarily disable o2 processing while formatting content.
-	add_filter( 'o2_process_the_content', '__return_false', 1 );
-	remove_filter( 'the_content', array( 'o2', 'add_json_data' ), 999999 );
+	// Temporarily disable o2 processing while formatting content, if the class exists.
+	$o2_exists = class_exists( 'o2' );
+	if ( $o2_exists ) {
+		add_filter( 'o2_process_the_content', '__return_false', 1 );
+		remove_filter( 'the_content', array( 'o2', 'add_json_data' ), 999999 );
+	}
+
 	$content = apply_filters( 'the_content', $content );
-	remove_filter( 'o2_process_the_content', '__return_false', 1 );
-	add_filter( 'the_content', array( 'o2', 'add_json_data' ), 999999 );
+
+	if ( $o2_exists ) {
+		remove_filter( 'o2_process_the_content', '__return_false', 1 );
+		add_filter( 'the_content', array( 'o2', 'add_json_data' ), 999999 );
+	}
 
 	// Create a unique placeholder for the content.
 	// Directly processing `$content` with `do_blocks` can lead to buggy layouts on make.wp.org.