-
Notifications
You must be signed in to change notification settings - Fork 0
/
Copy pathResearch.html
83 lines (81 loc) · 4.61 KB
/
Research.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title> Lee Lab: Research </title>
<link rel="stylesheet" href="./Research.css">
<!-- Google Font: 'Ubuntu', sans serif -->
<style>
@import url('https://fonts.googleapis.com/css2?family=Ubuntu:ital,wght@1,500&display=swap');
</style>
</head>
<body>
<!-- NavBar -->
<nav class="topnavbar">
<div class="withintopnavbar">
<div class="Logo-and-Button">
<a class="nav-logo" href="./Home.html"> <img src="./Images/Logo Pic New.png" alt="LeeLab Logo"> </a>
<button type="button" class="btn nav-btn"> = </button>
</div>
<div class="allnavlinks">
<a class="navlink" href="./Home.html"> Home </a>
<a class="navlink" href="./Research.html"> Research </a>
<a class="navlink" href="./People.html"> People </a>
<a class="navlink" href="./Publications.html"> Publications </a>
<a class="navlink" href="./Opportunities.html"> Opportunities </a>
<a class="navlink" href="./Contact.html"> Contact </a>
</div>
</div>
</nav>
<!-- End of NavBar -->
<!-- Body of Website -->
<main class="MainBody">
<div class="Research-Header">
<div class="Inner-Research-Header">
<h3 class="Research-Header-1"> Research Focus </h3>
<h3 class="Research-Header-2"> Membrane-less Organelles and Neurodegeneration </h3>
</div>
</div>
<div>
<!-- Research Focus 1 -->
<h3 class="Research-Body-Header-1"> RNA Granules and Protein Aggregation </h3>
<div class="Research-Focus-1">
<div class="Research-Image-1"> </div>
<p> RNA and RNA binding proteins form several distinct organelles in neurons, such as RNA processing bodies, stress granules, and RNA transport granules. A common cellular anomaly observed in neurodegenerative diseases is the accumulation of non-dynamic protein masses called aggregates or plaques. Many of the proteins that aggregate in disease are RNA binding proteins that concentrate in RNA granules. We recently discovered that mutations in RNA granule components cause the dynamic organelles to harden and transform into solid aggregates in vitro. Yet, this liquid-to-solid transition is not readily observed in cells, indicating that there are regulatory mechanisms that prevent protein aggregation inside RNA granules. </p>
</div>
<div class="to-understand">
<h4> We want to understand </h4>
<ul>
<li> What cellular factors ensure that proteins inside RNA granules remain soluble </li>
<li> What role RNA plays in the regulation of RNA granules </li>
<li> How protein aggregates impact other cellular processes </li>
</ul>
</div>
<!-- Research Focus 2 -->
<h3 class="Research-Body-Header-2"> DNA Damage Repair Sites and Neurodegeneration </h3>
<div class="Research-Focus-2">
<div class="Research-Image-2"> </div>
<p> One of the most commonly observed cellular defects in aged cells and in degenerating neurons is the accumulation of unrepaired DNA damage. We and others have shown that RNA binding proteins also localize to damaged DNA and form liquid-like membraneless organelles. Disease-associated mutations in these proteins lead to inefficient DNA repair and accumulation of unresolved DNA damage. </p>
</div>
<div class="to-determine">
<h4> We want to determine </h4>
<ul>
<li> How the assembly and composition of DNA repair sites are regulated </li>
<li> How disease-associated mutations on RNA binding proteins affect the function of DNA repair sites </li>
<li> How unresolved DNA damage influences neuron health and function </li>
</ul>
</div>
<!-- research Focus 3 -->
<h3 class="Research-Body-Header-3"> Cell Biology of Neuromuscular Diseases </h3>
<div class="Research-Focus-3">
<div class="Research-Image-3"> </div>
<p> Our goal is to elucidate the development and progression of neuromuscular degeneration, such as Amyotrophic Lateral Sclerosis. To do this, we will first use 2D neuron-muscle co-cultures to examine how neuromuscular connection is altered in patient-derived cells. In parallel, we will engineer a 3D tissue-like system to validate these findings and test repair and regeneration strategies. </p>
</div>
</div>
</main>
<!-- End of Body of Website -->
<script src="./script.js"></script>
</body>
</html>